Regeneration of Functional Neurons After Spinal Cord Injury via in situ NeuroD1-Mediated Astrocyte-to-Neuron Conversion

Spinal cord injury (SCI) often leads to impaired motor and sensory functions, partially because the injury-induced neuronal loss cannot be easily replenished through endogenous mechanisms. In vivo neuronal reprogramming has emerged as a novel technology to regenerate neurons from endogenous glial ce...

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Veröffentlicht in:Front Cell Dev Biol
Hauptverfasser: Puls, Brendan, Ding, Yan, Zhang, Fengyu, Pan, Mengjie, Lei, Zhuofan, Pei, Zifei, Jiang, Mei, Bai, Yuting, Forsyth, Cody, Metzger, Morgan, Rana, Tanvi, Zhang, Lei, Ding, Xiaoyun, Keefe, Matthew, Cai, Alice, Redilla, Austin, Lai, Michael, He, Kevin, Li, Hedong, Chen, Gong
Format: Artigo
Sprache:Inglês
Veröffentlicht: Frontiers Media S.A. 2020
Schlagworte:
Cell and Developmental Biology
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7793709/
https://ncbi.nlm.nih.gov/pubmed/33425896
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fcell.2020.591883
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