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The Delta-Specific Opioid Glycopeptide BBI-11008: CNS Penetration and Behavioral Analysis in a Preclinical Model of Levodopa-Induced Dyskinesia

In previous work we evaluated an opioid glycopeptide with mixed μ/δ-opioid receptor agonism that was a congener of leu-enkephalin, MMP-2200. The glycopeptide analogue showed penetration of the blood–brain barrier (BBB) after systemic administration to rats, as well as profound central effects in mod...

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Bibliografiske detaljer
Udgivet i:Int J Mol Sci
Main Authors: Bartlett, Mitchell J., Mabrouk, Omar S., Szabò, Lajos, Flores, Andrew J., Parent, Kate L., Bidlack, Jean M., Heien, Michael L., Kennedy, Robert T., Polt, Robin, Sherman, Scott J., Falk, Torsten
Format: Artigo
Sprog:Inglês
Udgivet: MDPI 2020
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7792611/
https://ncbi.nlm.nih.gov/pubmed/33374986
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/ijms22010020
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