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Mesenchymal stem cell-secreted prostaglandin E(2) ameliorates acute liver failure via attenuation of cell death and regulation of macrophage polarization

BACKGROUND: Acute liver failure (ALF) is an acute inflammatory liver disease with high mortality. Previous preclinical and clinical trials have confirmed that mesenchymal stem cell (MSC) is a promising therapeutic approach; however, the effect is not satisfied as the underlying molecular mechanisms...

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Vydáno v:Stem Cell Res Ther
Hlavní autoři: Wang, Jinglin, Liu, Yang, Ding, Haoran, Shi, Xiaolei, Ren, Haozhen
Médium: Artigo
Jazyk:Inglês
Vydáno: BioMed Central 2021
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7792134/
https://ncbi.nlm.nih.gov/pubmed/33413632
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13287-020-02070-2
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