Exosomal ANGPTL1 attenuates colorectal cancer liver metastasis by regulating Kupffer cell secretion pattern and impeding MMP9 induced vascular leakiness

BACKGROUND: Angiopoietin-like protein 1 (ANGPTL1) has been proved to suppress tumor metastasis in several cancers. However, its extracellular effects on the pre-metastatic niches (PMNs) are still unclear. ANGPTL1 has been identified in exosomes, while its function remains unknown. This study was des...

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Dettagli Bibliografici
Pubblicato in:J Exp Clin Cancer Res
Autori principali: Jiang, Kai, Chen, Haiyan, Fang, Yimin, Chen, Liubo, Zhong, Chenhan, Bu, Tongtong, Dai, Siqi, Pan, Xiang, Fu, Dongliang, Qian, Yucheng, Wei, Jingsun, Ding, Kefeng
Natura: Artigo
Lingua:Inglês
Pubblicazione: BioMed Central 2021
Soggetti:
Research
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC7792106/
https://ncbi.nlm.nih.gov/pubmed/33413536
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13046-020-01816-3
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