Molecular screening of PROKR2 gene in girls with idiopathic central precocious puberty

BACKGROUND: Prokineticin receptor 2 (PROKR2) loss of function mutations have been described as cause of hypogonadotropic hypogonadism. In 2017, a first case of central precocious puberty (CPP) caused by PROKR2 heterozygous gain of function mutation was described in a 3.5 years-old girl. No other cas...

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Enregistré dans:
Détails bibliographiques
Publié dans:Ital J Pediatr
Auteurs principaux: Aiello, Francesca, Cirillo, Grazia, Cassio, Alessandra, Di Mase, Raffaella, Tornese, Gianluca, Umano, Giuseppina R., Miraglia del Giudice, Emanuele, Grandone, Anna
Format: Artigo
Langue:Inglês
Publié: BioMed Central 2021
Sujets:
Research
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC7792053/
https://ncbi.nlm.nih.gov/pubmed/33413516
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13052-020-00951-z
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