FAK displacement from focal adhesions: a promising strategy to target processes implicated in cancer progression and metastasis

BACKGROUND: Focal adhesion kinase (FAK) is a non-receptor tyrosine kinase that is overexpressed or activated in several advanced-stage solid cancers. It is known to play both kinase-dependent and -independent roles in promoting tumor progression and metastasis. Numerous inhibitors, targeting either...

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Publicat a:Cell Commun Signal
Autors principals: Antoniades, Ioanna, Kyriakou, Maria, Charalambous, Anna, Kalalidou, Katerina, Christodoulou, Andri, Christoforou, Maria, Skourides, Paris A.
Format: Artigo
Idioma:Inglês
Publicat: BioMed Central 2021
Matèries:
Research
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC7791867/
https://ncbi.nlm.nih.gov/pubmed/33413438
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12964-020-00671-1
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