Cell surface GRP78 regulates BACE2 via lysosome-dependent manner to maintain mesenchymal phenotype of glioma stem cells

BACKGROUND: Glioma stem cells (GSCs) are considered the initial cells of gliomas, contributing to therapeutic resistance. Patient-derived GSCs well recapitulate the heterogeneity of their parent glioma tissues, which can be classified into different subtypes. Likewise, previous works identified GSCs...

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Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:J Exp Clin Cancer Res
Prif Awduron: Chen, Zihang, Wang, Huizhi, Zhang, Zongpu, Xu, Jianye, Qi, Yanhua, Xue, Hao, Gao, Zijie, Zhao, Rongrong, Wang, Shaobo, Zhang, Shouji, Qiu, Wei, Guo, Xing, Li, Gang
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: BioMed Central 2021
Pynciau:
Research
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC7791784/
https://ncbi.nlm.nih.gov/pubmed/33413577
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13046-020-01807-4
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