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Acid sphingomyelinase-dependent autophagic degradation of GPX4 is critical for the execution of ferroptosis
Ferroptosis is a type of regulated cell death characterized by ROS accumulation and devastating lipid peroxidation (LPO). The role of acid sphingomyelinase (ASM), a key enzyme in sphingolipid metabolism, in the induction of apoptosis has been studied; however, to date its role in ferroptosis is uncl...
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| Udgivet i: | Cell Death Dis |
|---|---|
| Main Authors: | , , , , , , |
| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
Nature Publishing Group UK
2021
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7791123/ https://ncbi.nlm.nih.gov/pubmed/33414455 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41419-020-03297-w |
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