DPP4/CD32b/NF-κB Circuit: A Novel Druggable Target for Inhibiting CRP-Driven Diabetic Nephropathy

Diabetic nephropathy (DN) is a major cause of end-stage renal disease, but treatment remains ineffective. C-reactive protein (CRP) is pathogenic in DN, which significantly correlated with dipeptidyl peptidase-4 (DPP4) expression in diabetic patients with unknown reason. Here, using our unique CRP(tg...

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Vydáno v:Mol Ther
Hlavní autoři: Tang, Patrick Ming-Kuen, Zhang, Ying-Ying, Hung, Jessica Shuk-Chun, Chung, Jeff Yat-Fai, Huang, Xiao-Ru, To, Ka-Fai, Lan, Hui-Yao
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society of Gene & Cell Therapy 2021
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Original Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7790911/
https://ncbi.nlm.nih.gov/pubmed/32956626
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ymthe.2020.08.017
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