Osteosarcoma and soft-tissue sarcomas with an immune infiltrate express PD-L1: relation to clinical outcome and Th1 pathway activation

Immune checkpoint proteins, such as PD-L1 and PD-1, are important in several cancers; however, their role in osteosarcoma (OSA) and soft tissue sarcoma (STS) remains unclear. Our aims were to determine whether subsets of OSA/STS harbor tumor-infiltrating lymphocytes (TILs) and express PD-L1, and how...

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Опубликовано в: :Oncoimmunology
Главные авторы: Wunder, Jay S., Lee, Minji J., Nam, Junghyun, Lau, Beatrice Y., Dickson, Brendan C., Pinnaduwage, Dushanthi, Bull, Shelley B., Ferguson, Peter C., Seto, Andrew, Gokgoz, Nalan, Andrulis, Irene L.
Формат: Artigo
Язык:Inglês
Опубликовано: Taylor & Francis 2020
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Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC7790526/
https://ncbi.nlm.nih.gov/pubmed/33457085
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/2162402X.2020.1737385
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