Enhanced expression of CD39 and CD73 on T cells in the regulation of anti-tumor immune responses

Synthesis of extracellular adenosine by the ectonucleotidases CD39 and CD73 represents an important pathway of immune suppression in the tumor microenvironment. Using two mouse models (RET transgenic melanoma and Panc02 orthotopic pancreatic adenocarcinoma), we identified an elevated frequency of ec...

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Detalhes bibliográficos
Publicado no:Oncoimmunology
Main Authors: Shevchenko, Ivan, Mathes, Andreas, Groth, Christopher, Karakhanova, Svetlana, Müller, Verena, Utikal, Jochen, Werner, Jens, Bazhin, Alexandr V., Umansky, Viktor
Formato: Artigo
Idioma:Inglês
Publicado em: Taylor & Francis 2020
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Back Matter
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7790505/
https://ncbi.nlm.nih.gov/pubmed/33457090
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/2162402X.2020.1744946
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