The E3/E4 ubiquitin conjugation factor UBE4B interacts with and ubiquitinates the HTLV-1 Tax oncoprotein to promote NF-κB activation

Human T-cell leukemia virus type 1 (HTLV-1) is the etiological agent of adult T-cell leukemia/lymphoma (ATLL), and the neurological disease HTLV-1-associated myelopathy/tropical spastic paraparesis (HAM/TSP). The HTLV-1 Tax protein persistently activates the NF-κB pathway to enhance the proliferatio...

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Bibliographic Details
Published in:PLoS Pathog
Main Authors: Mohanty, Suchitra, Han, Teng, Choi, Young Bong, Lavorgna, Alfonso, Zhang, Jiawen, Harhaj, Edward William
Format: Artigo
Language:Inglês
Published: Public Library of Science 2020
Subjects:
Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC7790423/
https://ncbi.nlm.nih.gov/pubmed/33362245
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.ppat.1008504
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