Distinct functions of senescence-associated immune responses in liver tumor surveillance and tumor progression.

Oncogene-induced senescence causes hepatocytes to secrete cytokines, which induce their immune-mediated clearance preventing tumor initiation, a process termed ‘senescence surveillance’. However, senescent hepatocytes give rise to hepatocellular carcinomas (HCC), if the senescence program is bypasse...

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Detalhes bibliográficos
Publicado no:Cancer Cell
Main Authors: Eggert, Tobias, Wolter, Katharina, Ji, Juling, Ma, Chi, Yevsa, Tetyana, Klotz, Sabrina, Medina-Echeverz, José, Longerich, Thomas, Forgues, Marshonna, Reisinger, Florian, Heikenwalder, Mathias, Wang, Xin Wei, Zender, Lars, Greten, Tim F.
Formato: Artigo
Idioma:Inglês
Publicado em: 2016
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7789819/
https://ncbi.nlm.nih.gov/pubmed/27728804
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ccell.2016.09.003
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