Human-derived NLS enhance the gene transfer efficiency of chitosan

Nuclear import is considered as one of the major limitations for non-viral gene delivery systems and the incorporation of nuclear localization signals (NLS) that mediate nuclear intake can be used as a strategy to enhance internalization of exogenous DNA. In this work, human-derived endogenous NLS p...

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Enregistré dans:
Détails bibliographiques
Publié dans:Biosci Rep
Auteurs principaux: Bitoque, Diogo B., Morais, Joana, Oliveira, Ana V., Sequeira, Raquel L., Calado, Sofia M., Fortunato, Tiago M., Simão, Sónia, Rosa da Costa, Ana M., Silva, Gabriela A.
Format: Artigo
Langue:Inglês
Publié: Portland Press Ltd. 2021
Sujets:
Biotechnology
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC7789810/
https://ncbi.nlm.nih.gov/pubmed/33305307
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1042/BSR20201026
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