R-Spondin1 enhances wnt signaling and decreases weight loss in short bowel syndrome zebrafish

BACKGROUND: R-spondins, including R-spondin 1 (RSPO1), are a family of Wnt ligands that help to activate the canonical Wnt/β-catenin pathway, which is critical for intestinal epithelial cell proliferation and maintenance of intestinal stem cells. This proliferation underpins the epithelial expansion...

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Udgivet i:Biochem Biophys Rep
Main Authors: Maselli, Kathryn M., Levin, Gabriel, Gee, Kristin M., Leeflang, Elisabeth J., Carreira, Ana Claudia O., Sogayar, Mari Cleide, Grikscheit, Tracy C.
Format: Artigo
Sprog:Inglês
Udgivet: Elsevier 2021
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7788494/
https://ncbi.nlm.nih.gov/pubmed/33437880
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bbrep.2020.100874
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