Metoprolol Impairs β1-Adrenergic Receptor-Mediated Vasodilation in Rat Cerebral Arteries: Implications for β-Blocker Therapy

The practice of prescribing β-blockers to lower blood pressure and mitigate perioperative cardiovascular events has been questioned because of reports of an increased risk of stroke. The benefit of β-blocker therapy primarily relies on preventing activation of cardiac β1-adrenergic receptors (ARs)....

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Udgivet i:J Pharmacol Exp Ther
Main Authors: Moore, Christopher L., Henry, David S., McClenahan, Samantha J., Ball, Kelly K., Rusch, Nancy J., Rhee, Sung W.
Format: Artigo
Sprog:Inglês
Udgivet: The American Society for Pharmacology and Experimental Therapeutics 2021
Fag:
Cardiovascular
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7788352/
https://ncbi.nlm.nih.gov/pubmed/33100271
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/jpet.120.000176
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