Isotyping and Semi-Quantitation of Monkey Anti-Drug Antibodies by Immunocapture Liquid Chromatography-Mass Spectrometry

There is an urgent demand to develop new technologies to characterize immunogenicity to biotherapeutics. Here, we developed an immunocapture LC-MS assay to isotype and semi-quantify monkey anti-drug antibodies (ADAs) to fully human monoclonal antibody (mAb) drugs. ADAs were isolated from serum sampl...

Celý popis

Uloženo v:
Podrobná bibliografie
Vydáno v:AAPS J
Hlavní autoři: Huang, Xiaoxiao, Xu, Xiaobin, Partridge, Michael A., Chen, Jihua, Koehler-Stec, Ellen, Sumner, Giane, Qiu, Haibo, Torri, Albert, Li, Ning
Médium: Artigo
Jazyk:Inglês
Vydáno: Springer International Publishing 2021
Témata:
Research Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7788027/
https://ncbi.nlm.nih.gov/pubmed/33404777
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1208/s12248-020-00538-w
Tagy: Přidat tag
Žádné tagy, Buďte první, kdo otaguje tento záznam!

Podobné jednotky