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Functional inhibition or genetic deletion of acid sphingomyelinase bacteriostatically inhibits Anaplasma phagocytophilum infection in vivo

Anaplasma phagocytophilum infects neutrophils to cause granulocytic anaplasmosis. It poorly infects mice deficient in acid sphingomyelinase (ASM), a lysosomal enzyme critical for cholesterol efflux, and wild-type mice treated with desipramine that functionally inhibits ASM. Whether inhibition or gen...

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Detalhes bibliográficos
Publicado no:Pathog Dis
Main Authors: Naimi, Waheeda A, Gumpf, Jacob J, Cockburn, Chelsea L, Camus, Sarah, Chalfant, Charles E, Li, Pin-Lan, Carlyon, Jason A
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2020
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7787905/
https://ncbi.nlm.nih.gov/pubmed/33220685
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/femspd/ftaa072
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