N6-methyladenosine dynamics in neurodevelopment and aging, and its potential role in Alzheimer’s disease

BACKGROUND: N6-methyladenosine (m(6)A) modification is known to impact many aspects of RNA metabolism, including mRNA stability and translation, and is highly prevalent in the brain. RESULTS: We show that m(6)A modification displays temporal and spatial dynamics during neurodevelopment and aging. Ge...

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Dettagli Bibliografici
Pubblicato in:Genome Biol
Autori principali: Shafik, Andrew M., Zhang, Feiran, Guo, Zhenxing, Dai, Qing, Pajdzik, Kinga, Li, Yangping, Kang, Yunhee, Yao, Bing, Wu, Hao, He, Chuan, Allen, Emily G., Duan, Ranhui, Jin, Peng
Natura: Artigo
Lingua:Inglês
Pubblicazione: BioMed Central 2021
Soggetti:
Research
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC7786910/
https://ncbi.nlm.nih.gov/pubmed/33402207
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13059-020-02249-z
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