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Vasodilator effects of sulforaphane in cerebral circulation: A critical role of endogenously produced hydrogen sulfide and arteriolar smooth muscle K(ATP) and BK channels in the brain

We investigated the effects of sulforaphane (SFN), an isothiocyanate from cruciferous vegetables, in the regulation of cerebral blood flow using cranial windows in newborn pigs. SFN administered topically (10 µM–1 mM) or systemically (0.4 mg/kg ip) caused immediate and sustained dilation of pial art...

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Bibliografiske detaljer
Udgivet i:J Cereb Blood Flow Metab
Main Authors: Parfenova, Helena, Liu, Jianxiong, Hoover, Daniel T, Fedinec, Alex L
Format: Artigo
Sprog:Inglês
Udgivet: SAGE Publications 2019
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7786849/
https://ncbi.nlm.nih.gov/pubmed/31594422
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1177/0271678X19878284
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