Induction of apoptosis by Shikonin through ROS-mediated intrinsic and extrinsic apoptotic pathways in primary effusion lymphoma

Primary effusion lymphoma (PEL) is an incurable non-Hodgkin's lymphoma and novel biology-based treatments are urgently needed in clinical settings. Shikonin (SHK), a napthoquinone derivative, has been used for the treatment of solid tumors. Here, we report that SHK is an effective agent for the...

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Vydáno v:Transl Oncol
Hlavní autoři: Alam, Md Masud, Kariya, Ryusho, Boonnate, Piyanard, Kawaguchi, Azusa, Okada, Seiji
Médium: Artigo
Jazyk:Inglês
Vydáno: Neoplasia Press 2021
Témata:
Original Research
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7785961/
https://ncbi.nlm.nih.gov/pubmed/33401054
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.tranon.2020.101006
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