TERT promoter mutation analysis for blood-based diagnosis and monitoring of gliomas

PURPOSE. Liquid biopsy offers a minimally invasive tool to diagnose and monitor the heterogeneous molecular landscape of tumors over time and therapy. Detection of TERT promoter mutations (C228T, C250T) in cfDNA has been successful for some systemic cancers but has yet to be demonstrated in gliomas,...

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Pubblicato in:Clin Cancer Res
Autori principali: Muralidharan, Koushik, Yekula, Anudeep, Small, Julia L., Rosh, Zachary S., Kang, Keiko M., Wang, Lan, Lau, Spencer, Zhang, Hui, Lee, Hakho, Bettegowda, Chetan, Chicoine, Michael R., Kalkanis, Steven N., Shankar, Ganesh M., Nahed, Brian V., Curry, William T., Jones, Pamela S., Cahill, Daniel P., Balaj, Leonora, Carter, Bob S.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2020
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC7785705/
https://ncbi.nlm.nih.gov/pubmed/33051308
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1078-0432.CCR-20-3083
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