Genomic analysis of germline variation associated with survival of colorectal cancer patients treated with chemotherapy plus biologics in CALGB/SWOG 80405 (Alliance)

BACKGROUND: Irinotecan/5-FU (FOLFIRI) or oxaliplatin/5-FU (FOLFOX), combined with bevacizumab or cetuximab, are approved, first-line treatments for metastatic colorectal cancer (mCRC). We aimed at identifying germline variants associated with survival in mCRC patients treated with these regimens in...

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Gepubliceerd in:Clin Cancer Res
Hoofdauteurs: Innocenti, Federico, Sibley, Alexander B., Patil, Sushant A., Etheridge, Amy S., Jiang, Chen, Ou, Fang-Shu, Howell, Stefanie D., Plummer, Sarah J, Casey, Graham, Bertagnolli, Monica M., McLeod, Howard L., Auman, James T., Blanke, Charles D., Furukawa, Yoichi, Venook, Alan P., Kubo, Michiaki, Lenz, Heinz-Josef, Parker, Joel S., Ratain, Mark J., Owzar, Kouros
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: 2020
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Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7785628/
https://ncbi.nlm.nih.gov/pubmed/32958699
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1078-0432.CCR-20-2021
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