Development of spray-dried amorphous solid dispersions of tadalafil using glycyrrhizin for enhanced dissolution and aphrodisiac activity in male rats

Tadalafil (TDL) is a phosphodiesterase-5 inhibitor (PDE5I), indicated for erectile dysfunction (ED). However, TDL exhibits poor aqueous solubility and dissolution rate, which may limit its application. This study aims to prepare amorphous solid dispersion (ASD) by spray-drying, using glycyrrhizin-a...

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Dades bibliogràfiques
Publicat a:Saudi Pharm J
Autors principals: Muqtader Ahmed, Mohammed, Fatima, Farhat, Abul Kalam, Mohd, Alshamsan, Aws, Soliman, Gamal A., Shaikh, Abdul Azim, Alshahrani, Saad M, Aldawsari, Mohammed F., Bhatia, Saurabh, Khalid Anwer, Md.
Format: Artigo
Idioma:Inglês
Publicat: Elsevier 2020
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC7783211/
https://ncbi.nlm.nih.gov/pubmed/33424269
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jsps.2020.11.007
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