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Global computational alignment of tumor and cell line transcriptional profiles

Cell lines are key tools for preclinical cancer research, but it remains unclear how well they represent patient tumor samples. Direct comparisons of tumor and cell line transcriptional profiles are complicated by several factors, including the variable presence of normal cells in tumor samples. We...

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Detalhes bibliográficos
Publicado no:Nat Commun
Main Authors: Warren, Allison, Chen, Yejia, Jones, Andrew, Shibue, Tsukasa, Hahn, William C., Boehm, Jesse S., Vazquez, Francisca, Tsherniak, Aviad, McFarland, James M.
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2021
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7782593/
https://ncbi.nlm.nih.gov/pubmed/33397959
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-020-20294-x
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