Deletion of Trim28 in committed adipocytes promotes obesity but preserves glucose tolerance

The effective storage of lipids in white adipose tissue (WAT) critically impacts whole body energy homeostasis. Many genes have been implicated in WAT lipid metabolism, including tripartite motif containing 28 (Trim28), a gene proposed to primarily influence adiposity via epigenetic mechanisms in em...

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Vydáno v:Nat Commun
Hlavní autoři: Bond, Simon T., King, Emily J., Henstridge, Darren C., Tran, Adrian, Moody, Sarah C., Yang, Christine, Liu, Yingying, Mellett, Natalie A., Nath, Artika P., Inouye, Michael, Tarling, Elizabeth J., de Aguiar Vallim, Thomas Q., Meikle, Peter J., Calkin, Anna C., Drew, Brian G.
Médium: Artigo
Jazyk:Inglês
Vydáno: Nature Publishing Group UK 2021
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7782476/
https://ncbi.nlm.nih.gov/pubmed/33397965
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-020-20434-3
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