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Graded titin cleavage progressively reduces tension and uncovers the source of A-band stability in contracting muscle
The giant muscle protein titin is a major contributor to passive force; however, its role in active force generation is unresolved. Here, we use a novel titin-cleavage (TC) mouse model that allows specific and rapid cutting of elastic titin to quantify how titin-based forces define myocyte ultrastru...
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| Publié dans: | eLife |
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| Auteurs principaux: | , , , , , , , |
| Format: | Artigo |
| Langue: | Inglês |
| Publié: |
eLife Sciences Publications, Ltd
2020
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| Sujets: | |
| Accès en ligne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7781594/ https://ncbi.nlm.nih.gov/pubmed/33357376 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.64107 |
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