Urinary Leukotriene E(4) and Prostaglandin D(2) Metabolites Increase in Adult and Childhood Severe Asthma Characterized by Type 2 Inflammation. A Clinical Observational Study

Rationale: New approaches are needed to guide personalized treatment of asthma. Objectives: To test if urinary eicosanoid metabolites can direct asthma phenotyping. Methods: Urinary metabolites of prostaglandins (PGs), cysteinyl leukotrienes (CysLTs), and isoprostanes were quantified in the U-BIOPRE...

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Detalhes bibliográficos
Publicado no:Am J Respir Crit Care Med
Main Authors: Kolmert, Johan, Gómez, Cristina, Balgoma, David, Sjödin, Marcus, Bood, Johan, Konradsen, Jon R., Ericsson, Magnus, Thörngren, John-Olof, James, Anna, Mikus, Maria, Sousa, Ana R., Riley, John H., Bates, Stewart, Bakke, Per S., Pandis, Ioannis, Caruso, Massimo, Chanez, Pascal, Fowler, Stephen J., Geiser, Thomas, Howarth, Peter, Horváth, Ildikó, Krug, Norbert, Montuschi, Paolo, Sanak, Marek, Behndig, Annelie, Shaw, Dominick E., Knowles, Richard G., Holweg, Cécile T. J., Wheelock, Åsa M., Dahlén, Barbro, Nordlund, Björn, Alving, Kjell, Hedlin, Gunilla, Chung, Kian Fan, Adcock, Ian M., Sterk, Peter J., Djukanovic, Ratko, Dahlén, Sven-Erik
Formato: Artigo
Idioma:Inglês
Publicado em: American Thoracic Society 2021
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Original Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7781128/
https://ncbi.nlm.nih.gov/pubmed/32667261
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1164/rccm.201909-1869OC
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