The Hepatitis C virus NS5A and core proteins exert antagonistic effects on HAMP gene expression: the hidden interplay with the MTF‐1/MRE pathway

Hepcidin, a 25‐amino acid peptide encoded by the HAMP gene and produced mainly by hepatocytes and macrophages, is a mediator of innate immunity and the central iron‐regulatory hormone. Circulating hepcidin controls iron efflux by inducing degradation of the cellular iron exporter ferroportin. HCV in...

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Detalhes bibliográficos
Publicado no:FEBS Open Bio
Main Authors: Dimitriadis, Alexios, Foka, Pelagia, Kyratzopoulou, Eleni, Karamichali, Eirini, Petroulia, Stavroula, Tsitoura, Panagiota, Kakkanas, Athanasios, Eliadis, Petros, Georgopoulou, Urania, Mamalaki, Avgi
Formato: Artigo
Idioma:Inglês
Publicado em: John Wiley and Sons Inc. 2020
Assuntos:
Research Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7780115/
https://ncbi.nlm.nih.gov/pubmed/33247551
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/2211-5463.13048
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