CD24, not CD47, negatively impacts upon response to PD‐1/L1 inhibitors in non–small‐cell lung cancer with PD‐L1 tumor proportion score < 50

CD24, a heavily glycosylated glycosylphosphatidylinositol–anchored surface protein, inhibits phagocytosis as potently as CD47. The relationship between such anti‐phagocytic factors and the immune response with immune–checkpoint inhibitors (ICI) remains unexplored. We evaluated CD24 and CD47 tumor pr...

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Detalhes bibliográficos
Publicado no:Cancer Sci
Main Authors: Ozawa, Yuichi, Harutani, Yuhei, Oyanagi, Jun, Akamatsu, Hiroaki, Murakami, Eriko, Shibaki, Ryota, Hayata, Atsushi, Sugimoto, Takeya, Tanaka, Masanori, Takakura, Toshiaki, Furuta, Katsuyuki, Okuda, Yuka, Sato, Kouichi, Teraoka, Shunsuke, Ueda, Hiroki, Tokudome, Nahomi, Kitamura, Yuka, Fukuoka, Junya, Nakanishi, Masanori, Koh, Yasuhiro, Yamamoto, Nobuyuki
Formato: Artigo
Idioma:Inglês
Publicado em: John Wiley and Sons Inc. 2020
Assuntos:
Basic and Clinical Immunology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7780034/
https://ncbi.nlm.nih.gov/pubmed/33084148
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/cas.14705
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