Prune-1 drives polarization of tumor-associated macrophages (TAMs) within the lung metastatic niche in triple-negative breast cancer

M2-tumor-associated macrophages (M2-TAMs) in the tumor microenvironment represent a prognostic indicator for poor outcome in triple-negative breast cancer (TNBC). Here we show that Prune-1 overexpression in human TNBC patients has positive correlation to lung metastasis and infiltrating M2-TAMs. Thu...

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Publicado no:iScience
Main Authors: Ferrucci, Veronica, Asadzadeh, Fatemeh, Collina, Francesca, Siciliano, Roberto, Boccia, Angelo, Marrone, Laura, Spano, Daniela, Carotenuto, Marianeve, Chiarolla, Cristina Maria, De Martino, Daniela, De Vita, Gennaro, Macrì, Alessandra, Dassi, Luisa, Vandenbussche, Jonathan, Marino, Natascia, Cantile, Monica, Paolella, Giovanni, D'Andrea, Francesco, di Bonito, Maurizio, Gevaert, Kris, Zollo, Massimo
Formato: Artigo
Idioma:Inglês
Publicado em: Elsevier 2020
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7779777/
https://ncbi.nlm.nih.gov/pubmed/33426510
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.isci.2020.101938
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