Cotrimoxazole Prophylaxis Increases Resistance Gene Prevalence and α-Diversity but Decreases β-Diversity in the Gut Microbiome of Human Immunodeficiency Virus–Exposed, Uninfected Infants

BACKGROUND: Prophylactic cotrimoxazole treatment is recommended in human immunodeficiency virus (HIV)–exposed, uninfected (HEU) infants, but the effects of this treatment on developing HEU infant gut microbiotas and resistomes are largely undefined. METHODS: We analyzed whole-metagenome sequencing d...

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Detalhes bibliográficos
Publicado no:Clin Infect Dis
Main Authors: D’Souza, Alaric W, Moodley-Govender, Eshia, Berla, Bertram, Kelkar, Tejas, Wang, Bin, Sun, Xiaoqing, Daniels, Brodie, Coutsoudis, Anna, Trehan, Indi, Dantas, Gautam
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2019
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Major Articles and Commentaries
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7778358/
https://ncbi.nlm.nih.gov/pubmed/31832638
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/cid/ciz1186
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