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mTOR inhibition acts as an unexpected checkpoint in p53-mediated tumor suppression
Here, we showed that the acetylation-defective p53-4KR mice, lacking the ability of cell cycle arrest, senescence, apoptosis, and ferroptosis, were tumor prone but failed to develop early-onset tumors. By identifying a novel p53 acetylation site at lysine K136, we found that simultaneous mutations a...
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| Udgivet i: | Genes Dev |
|---|---|
| Main Authors: | , , , , , |
| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
Cold Spring Harbor Laboratory Press
2021
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7778266/ https://ncbi.nlm.nih.gov/pubmed/33303641 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gad.340919.120 |
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