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mTOR inhibition acts as an unexpected checkpoint in p53-mediated tumor suppression

Here, we showed that the acetylation-defective p53-4KR mice, lacking the ability of cell cycle arrest, senescence, apoptosis, and ferroptosis, were tumor prone but failed to develop early-onset tumors. By identifying a novel p53 acetylation site at lysine K136, we found that simultaneous mutations a...

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Dettagli Bibliografici
Pubblicato in:Genes Dev
Autori principali: Kon, Ning, Ou, Yang, Wang, Shang-Jui, Li, Huan, Rustgi, Anil K., Gu, Wei
Natura: Artigo
Lingua:Inglês
Pubblicazione: Cold Spring Harbor Laboratory Press 2021
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC7778266/
https://ncbi.nlm.nih.gov/pubmed/33303641
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gad.340919.120
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