Pharmaco-Optogenetic Targeting of TRPC Activity Allows for Precise Control Over Mast Cell NFAT Signaling

Canonical transient receptor potential (TRPC) channels are considered as elements of the immune cell Ca(2+) handling machinery. We therefore hypothesized that TRPC photopharmacology may enable uniquely specific modulation of immune responses. Utilizing a recently established TRPC3/6/7 selective, pho...

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Опубликовано в: :Front Immunol
Главные авторы: Bacsa, Bernadett, Graziani, Annarita, Krivic, Denis, Wiedner, Patrick, Malli, Roland, Rauter, Thomas, Tiapko, Oleksandra, Groschner, Klaus
Формат: Artigo
Язык:Inglês
Опубликовано: Frontiers Media S.A. 2020
Предметы:
Immunology
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC7775509/
https://ncbi.nlm.nih.gov/pubmed/33391284
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fimmu.2020.613194
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