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A chloride channel blocker prevents the suppression by inorganic phosphate of the cytosolic calcium signals that control muscle contraction.
Fatiguing exercise causes hydrolysis of phosphocreatine, increasing the intracellular concentration of inorganic phosphate (P(i)). P(i) diffuses into the sarcoplasmic reticulum (SR) where it is believed to forms insoluble Ca(2+) salts, thus contributing to the impairment of Ca(2+) release. Informati...
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| Publicado no: | J Physiol |
|---|---|
| Main Authors: | , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2020
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7775353/ https://ncbi.nlm.nih.gov/pubmed/32991741 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1113/JP279917 |
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