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Cocaine self-administration abolishes endocannabinoid-mediated long-term depression of glutamatergic synapses in the ventral tegmental area

Drugs of abuse, including cocaine, alter the mechanisms underpinning synaptic plasticity, including long-term potentiation of glutamatergic synapses in the mesolimbic system. These effects are thought to underlie addictive behaviors. In the ventral tegmental area (VTA), glutamatergic synapses also e...

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Détails bibliographiques
Publié dans:Eur J Neurosci
Auteurs principaux: Wang, Ruixiang, Hausknecht, Kathryn A., Gancarz-Kausch, Amy M., Oubraim, Saida, Shen, Roh-Yu, Haj-Dahmane, Samir
Format: Artigo
Langue:Inglês
Publié: 2020
Sujets:
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC7775329/
https://ncbi.nlm.nih.gov/pubmed/32959420
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/ejn.14980
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