Single Point Mutation from E22-to-K in Aβ Initiates Early-Onset Alzheimer's Disease by Binding with Catalase

Amyloid-beta (Aβ) is a critical etiological factor for late-onset familial Alzheimer's disease (AD). However, an early-onset AD has been found to be related with an Aβ mutation in glutamic acid 22-to-lysine (Italian type E22K). Why only one single point mutation at E22 residue induces AD remain...

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Bibliografische gegevens
Gepubliceerd in:Oxid Med Cell Longev
Hoofdauteurs: Jiang, Wenjing, YanYu, Yao, Dandan, Fei, Xuechao, Ai, Li, Di, Yalan, Zhang, Jingnan, Yue, Xiangpei, Zhao, Shengjie, He, Rongqiao, Lyu, Jihui, Tong, Zhiqian
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: Hindawi 2020
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Research Article
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7775154/
https://ncbi.nlm.nih.gov/pubmed/33425208
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1155/2020/4981204
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