Structural Insights into the Atomistic Mechanisms of Uric Acid Recognition and Translocation of Human Urate Anion Transporter 1

[Image: see text] Background: Human urate transporter 1 (hURAT1) is the most pivotal therapeutic target for treating hyperuricemia. However, the molecular interactions between uric acid and URAT1 are still unknown due to lack of structural details. Methods: In the present study, several methods (hom...

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Udgivet i:ACS Omega
Main Authors: Zhao, Ze’an, Jiang, Yu, Li, Lu, Chen, Yanyu, Li, Yongmei, Lan, Qunsheng, Wu, Ting, Lin, Cuiting, Cao, Ying, Nandakumar, Kutty Selva, Zhou, Pingzheng, Tian, Yuanxin, Pang, Jianxin
Format: Artigo
Sprog:Inglês
Udgivet: American Chemical Society 2020
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7774290/
https://ncbi.nlm.nih.gov/pubmed/33403304
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acsomega.0c05360
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