Modulation of the Acetylcholine Receptor Clustering Pathway Improves Neuromuscular Junction Structure and Muscle Strength in a Mouse Model of Congenital Myasthenic Syndrome

Introduction: Congenital myasthenic syndromes (CMS) are a diverse group of inherited neuromuscular disorders characterized by a failure of synaptic transmission at the neuromuscular junction (NMJ). CMS often present early with fatigable weakness and can be fatal through respiratory complications. Th...

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Опубликовано в: :Front Mol Neurosci
Главные авторы: Spendiff, Sally, Howarth, Rachel, McMacken, Grace, Davey, Tracey, Quinlan, Kaitlyn, O'Connor, Emily, Slater, Clarke, Hettwer, Stefan, Mäder, Armin, Roos, Andreas, Horvath, Rita, Lochmüller, Hanns
Формат: Artigo
Язык:Inglês
Опубликовано: Frontiers Media S.A. 2020
Предметы:
Neuroscience
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC7773664/
https://ncbi.nlm.nih.gov/pubmed/33390901
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fnmol.2020.594220
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