Structural Differences in Translation Initiation between Pathogenic Trypanosomatids and Their Mammalian Hosts

Canonical mRNA translation in eukaryotes begins with the formation of the 43S pre-initiation complex (PIC). Its assembly requires binding of initiator Met-tRNA(i)(Met) and several eukaryotic initiation factors (eIFs) to the small ribosomal subunit (40S). Compared to their mammalian hosts, trypanosom...

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Detalhes bibliográficos
Publicado no:Cell Rep
Main Authors: Bochler, Anthony, Querido, Jailson Brito, Prilepskaja, Terezie, Soufari, Heddy, Simonetti, Angelita, Del Cistia, Mayara Lucia, Kuhn, Lauriane, Ribeiro, Aline Rimoldi, Valášek, Leoš Shivaya, Hashem, Yaser
Formato: Artigo
Idioma:Inglês
Publicado em: Cell Press 2020
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7773551/
https://ncbi.nlm.nih.gov/pubmed/33357443
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2020.108534
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