mTOR-dependent translation amplifies microglia priming in aging mice

Microglia maintain homeostasis in the brain. However, with age, they become primed and respond more strongly to inflammatory stimuli. We show here that microglia from aged mice had upregulated mTOR complex 1 signaling controlling translation, as well as protein levels of inflammatory mediators. Gene...

ver descrição completa

Na minha lista:
Detalhes bibliográficos
Publicado no:J Clin Invest
Main Authors: Keane, Lily, Antignano, Ignazio, Riechers, Sean-Patrick, Zollinger, Raphael, Dumas, Anaelle A., Offermann, Nina, Bernis, Maria E., Russ, Jenny, Graelmann, Frederike, McCormick, Patrick Neil, Esser, Julia, Tejera, Dario, Nagano, Ai, Wang, Jun, Chelala, Claude, Biederbick, Yvonne, Halle, Annett, Salomoni, Paolo, Heneka, Michael T., Capasso, Melania
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Clinical Investigation 2021
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7773382/
https://ncbi.nlm.nih.gov/pubmed/33108356
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI132727
Tags: Adicionar Tag
Sem tags, seja o primeiro a adicionar uma tag!

Registos relacionados