Neuronal hyperexcitability is a DLK-dependent trigger of herpes simplex virus reactivation that can be induced by IL-1

Herpes simplex virus-1 (HSV-1) establishes a latent infection in neurons and periodically reactivates to cause disease. The stimuli that trigger HSV-1 reactivation have not been fully elucidated. We demonstrate HSV-1 reactivation from latently infected mouse neurons induced by forskolin requires neu...

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Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:eLife
Prif Awduron: Cuddy, Sean R, Schinlever, Austin R, Dochnal, Sara, Seegren, Philip V, Suzich, Jon, Kundu, Parijat, Downs, Taylor K, Farah, Mina, Desai, Bimal N, Boutell, Chris, Cliffe, Anna R
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: eLife Sciences Publications, Ltd 2020
Pynciau:
Microbiology and Infectious Disease
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC7773336/
https://ncbi.nlm.nih.gov/pubmed/33350386
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.58037
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