The mitochondria-targeted derivative of the classical uncoupler of oxidative phosphorylation carbonyl cyanide m-chlorophenylhydrazone is an effective mitochondrial recoupler

The synthesis of a mitochondria-targeted derivative of the classical mitochondrial uncoupler carbonyl cyanide-m-chlorophenylhydrazone (CCCP) by alkoxy substitution of CCCP with n-decyl(triphenyl)phosphonium cation yielded mitoCCCP, which was able to inhibit the uncoupling action of CCCP, tyrphostin...

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Publicat a:PLoS One
Autors principals: Iaubasarova, Iliuza R., Khailova, Ljudmila S., Firsov, Alexander M., Grivennikova, Vera G., Kirsanov, Roman S., Korshunova, Galina A., Kotova, Elena A., Antonenko, Yuri N.
Format: Artigo
Idioma:Inglês
Publicat: Public Library of Science 2020
Matèries:
Research Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC7773232/
https://ncbi.nlm.nih.gov/pubmed/33378414
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0244499
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