An ultrasensitive biosensor for high-resolution kinase activity imaging in awake mice

Protein kinases control nearly every facet of cellular function. These key signaling nodes integrate diverse pathway inputs to regulate complex physiological processes, and aberrant kinase signaling is linked to numerous pathologies. While fluorescent protein-based biosensors have revolutionized the...

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Vydáno v:Nat Chem Biol
Hlavní autoři: Zhang, Jin-Fan, Liu, Bian, Hong, Ingie, Mo, Albert, Roth, Richard H., Tenner, Brian, Lin, Wei, Zhang, Jason Z., Molina, Rosana S., Drobizhev, Mikhail, Hughes, Thomas E., Tian, Lin, Huganir, Richard L., Mehta, Sohum, Zhang, Jin
Médium: Artigo
Jazyk:Inglês
Vydáno: 2020
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7773213/
https://ncbi.nlm.nih.gov/pubmed/32989297
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41589-020-00660-y
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