Inhibition of the replication of SARS-CoV-2 in human cells by the FDA-approved drug chlorpromazine

INTRODUCTION: Urgent action is needed to fight the ongoing coronavirus disease 2019 (COVID-19) pandemic by reducing the number of infected cases, contagiousness and severity. Chlorpromazine (CPZ), an antipsychotic from the phenothiazine group, is known to inhibit clathrin-mediated endocytosis and ha...

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Vydáno v:Int J Antimicrob Agents
Hlavní autoři: Plaze, Marion, Attali, David, Prot, Matthieu, Petit, Anne-Cécile, Blatzer, Michael, Vinckier, Fabien, Levillayer, Laurine, Chiaravalli, Jeanne, Perin-Dureau, Florent, Cachia, Arnaud, Friedlander, Gérard, Chrétien, Fabrice, Simon-Loriere, Etienne, Gaillard, Raphaël
Médium: Artigo
Jazyk:Inglês
Vydáno: Elsevier Ltd and International Society of Antimicrobial Chemotherapy. 2021
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7772996/
https://ncbi.nlm.nih.gov/pubmed/33387629
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ijantimicag.2020.106274
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