Calculating the net clinical benefit in neuro-oncology clinical trials using two methods: quality-adjusted survival effect sizes and joint modeling

BACKGROUND: Two methods combining survival and health-related quality of life (HRQoL) data in glioma trials to calculate the “net clinical benefit” were evaluated: Quality-adjusted effect sizes (QASES) and joint modeling (JM). METHODS: The net clinical benefit in two trials was calculated as proof o...

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Veröffentlicht in:Neurooncol Adv
Hauptverfasser: Coomans, Marijke B, Dirven, Linda, Aaronson, Neil K, Baumert, Brigitta G, van den Bent, Martin, Bottomley, Andrew, Brandes, Alba A, Chinot, Olivier, Coens, Corneel, Gorlia, Thierry, Herrlinger, Ulrich, Keime-Guibert, Florence, Malmström, Annika, Martinelli, Francesca, Sloan, Jeff A, Stupp, Roger, Talacchi, Andrea, Weller, Michael, Wick, Wolfgang, Reijneveld, Jaap C, Taphoorn, Martin J B
Format: Artigo
Sprache:Inglês
Veröffentlicht: Oxford University Press 2020
Schlagworte:
Clinical Investigations
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7772555/
https://ncbi.nlm.nih.gov/pubmed/33409496
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/noajnl/vdaa147
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