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Assessing the risk of ketoacidosis due to sodium-glucose cotransporter (SGLT)-2 inhibitors in patients with type 1 diabetes: A meta-analysis and meta-regression

BACKGROUND: Sodium-glucose cotransporter-2 (SGLT2) inhibitors (SGLT2i) showed benefits in type 1 diabetes mellitus (T1DM), but the risk of diabetic ketoacidosis (DKA) limits their use. Ability to predict DKA risk and therapeutic responses would enable appropriate patient selection for SGLT2i. We con...

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Détails bibliographiques
Publié dans:PLoS Med
Auteurs principaux: Musso, Giovanni, Sircana, Antonio, Saba, Francesca, Cassader, Maurizio, Gambino, Roberto
Format: Artigo
Langue:Inglês
Publié: Public Library of Science 2020
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Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC7771708/
https://ncbi.nlm.nih.gov/pubmed/33373368
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pmed.1003461
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