Polygenic risk of psychiatric disorders exhibits cross-trait associations in electronic health record data from European ancestry individuals

BACKGROUND: Prediction of disease risk is a key component of precision medicine. Common traits such as psychiatric disorders have a complex polygenic architecture making the identification of a single risk predictor difficult. Polygenic risk scores (PRS) denoting the sum of an individual’s genetic l...

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Vydáno v:Biol Psychiatry
Hlavní autoři: Kember, Rachel L., Merikangas, Alison K., Verma, Shefali S., Verma, Anurag, Judy, Renae, Damrauer, Scott M., Ritchie, Marylyn D., Rader, Daniel J., Bućan, Maja
Médium: Artigo
Jazyk:Inglês
Vydáno: 2020
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7770066/
https://ncbi.nlm.nih.gov/pubmed/32919613
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.biopsych.2020.06.026
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