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A framework for considering the risk-benefit trade-off in designing noninferiority trials using composite outcome approaches
When a new treatment regimen is expected to have comparable or slightly worse efficacy to that of the control regimen but has benefits in other domains such as safety and tolerability, a non-inferiority (NI) trial may be appropriate but is fraught with difficulty in justifying an acceptable NI margi...
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| Publicado no: | Stat Med |
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| Main Authors: | , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2020
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7770022/ https://ncbi.nlm.nih.gov/pubmed/33105524 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/sim.8777 |
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