Extracellular vesicles containing ACE2 efficiently prevent infection by SARS‐CoV‐2 Spike protein‐containing virus

SARS‐CoV‐2 entry is mediated by binding of the spike protein (S) to the surface receptor ACE2 and subsequent priming by host TMPRSS2 allowing membrane fusion. Here, we produced extracellular vesicles (EVs) exposing ACE2 and demonstrate that ACE2‐EVs are efficient decoys for SARS‐CoV‐2 S protein‐cont...

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Detalhes bibliográficos
Publicado no:J Extracell Vesicles
Main Authors: Cocozza, Federico, Névo, Nathalie, Piovesana, Ester, Lahaye, Xavier, Buchrieser, Julian, Schwartz, Olivier, Manel, Nicolas, Tkach, Mercedes, Théry, Clotilde, Martin‐Jaular, Lorena
Formato: Artigo
Idioma:Inglês
Publicado em: John Wiley and Sons Inc. 2020
Assuntos:
Short Communication
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7769856/
https://ncbi.nlm.nih.gov/pubmed/33391636
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/jev2.12050
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